ОСОБЕННОСТИ МОРФОЛОГИИ И РАСПРЕДЕЛЕНИЯ ОПУХОЛЬ- АССОЦИИРОВАННЫХ МАКРОФАГОВ В КОЛОРЕКТАЛЬНЫХ КАРЦИНОМАХ
Ключевые слова:
макрофаг,Аннотация
Изучена морфология и распределение опухоль ассоциированных макрофагов в колоректальных карциномах. Установлено, что макрофаги в ткани опухоли распределены неравномерно и отличаются морфологически. Наибольшая плотность макрофагальной инфильтрации отмечена в окружающей опухоль строме. В опухоли и пограничной слизистой различия в плотности макрофагальной инфильтрации статистически недостоверны (p=0,63). Тоқ ішектегі ісікпен байланысты макрофагтардың бөлінуі мен морфологиялары зерттелді. Ісіктің ішіндегі макрофагтардың бөлинуі біркелкі еместігі жəне олардың морфологиясының бір- бірінен өзгешелігі дəлелденді. Ісікті қоршаған стромада макрофагтың ең көп болатындығы көрсетілді. Ісік пен ісік жанындағы макрофаг саны статистика көрсеткіштері бойынша біркелкі (p=0,63).Библиографические ссылки
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2 van Ravenswaay-Claasen H.H. et al. Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity // Lab Invest. 1992. Vol. 67. P. 166-174
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3 O’Sullivan C., Lewis C.E., Harris A.L., McGee J.O. Secretion of epidermal growth factor by macrophages associated with breast carcinoma // Lancet, 1993. Vol. 342. P. 148-149.
4 Toomey D. et al. Phenotyping of immune cell infiltrates in breast and colorectal tumours // Immunol Invest, 1999. Vol. 28. P. 29-41.
5 Mantovani A., Ming W.J., Balotta C., Abdeljalil B., Bottazzi B. Origin and regulation of tumorassociated macrophages: the role of tumor-derived chemotactic factor // Biochim Biophys Acta, 1986. Vol.
865. P. 59-67.
6 Volodko N., Reiner A., Rudas M., Jakesz R. Tumour-associated macrophages in breast cancer and their prognostic correlations // Breast, 1998. №7. P. 99-105.
7 Mills C.D., Shearer J., Evans R., Caldwell M.D. Macrophage arginine metabolism and the inhibition or stimulation of cancer // J Immunol, 1992. Vol. 149. P. 2709-2714.
8 Elgert K.D., Alleva D.G., Mullins D.W. Tumor-induced immune dysfunction: the macrophage connection // J Leukoc Biol, 1998. Vol. 64. P. 275-290.
9 Grabbe S. et al. Interferon-gamma inhibits tumor antigen presentation by epidermal antigenpresenting cells // J Leukoc Biol, 1994. Vol. 55. P. 695-701.
10 Blachere N.E. et al. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptidespecific cytotoxic T-lymphocyte response and tumor immunity // J Exp Med, 1997. Vol. 186. P. 1315-1322.
11 Sunderkotter C. et al. Macrophages and angiogenesis // J Leukoc Biol, 1994. Vol. 55. P. 410-422.
2 van Ravenswaay-Claasen H.H. et al. Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity // Lab Invest. 1992. Vol. 67. P. 166-174
.
3 O’Sullivan C., Lewis C.E., Harris A.L., McGee J.O. Secretion of epidermal growth factor by macrophages associated with breast carcinoma // Lancet, 1993. Vol. 342. P. 148-149.
4 Toomey D. et al. Phenotyping of immune cell infiltrates in breast and colorectal tumours // Immunol Invest, 1999. Vol. 28. P. 29-41.
5 Mantovani A., Ming W.J., Balotta C., Abdeljalil B., Bottazzi B. Origin and regulation of tumorassociated macrophages: the role of tumor-derived chemotactic factor // Biochim Biophys Acta, 1986. Vol.
865. P. 59-67.
6 Volodko N., Reiner A., Rudas M., Jakesz R. Tumour-associated macrophages in breast cancer and their prognostic correlations // Breast, 1998. №7. P. 99-105.
7 Mills C.D., Shearer J., Evans R., Caldwell M.D. Macrophage arginine metabolism and the inhibition or stimulation of cancer // J Immunol, 1992. Vol. 149. P. 2709-2714.
8 Elgert K.D., Alleva D.G., Mullins D.W. Tumor-induced immune dysfunction: the macrophage connection // J Leukoc Biol, 1998. Vol. 64. P. 275-290.
9 Grabbe S. et al. Interferon-gamma inhibits tumor antigen presentation by epidermal antigenpresenting cells // J Leukoc Biol, 1994. Vol. 55. P. 695-701.
10 Blachere N.E. et al. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptidespecific cytotoxic T-lymphocyte response and tumor immunity // J Exp Med, 1997. Vol. 186. P. 1315-1322.
11 Sunderkotter C. et al. Macrophages and angiogenesis // J Leukoc Biol, 1994. Vol. 55. P. 410-422.
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ГИСТОЛОГИЯ, ЦИТОЛОГИЯ, КЛЕТОЧНАЯ БИОЛОГИЯ
