ОСОБЕННОСТИ СВЯЗЫВАНИЯ МЕЖГЕННЫХ И ИНТРОННЫХ miRNA С mRNA ГЕНА Е-КАДЕРИНА ЧЕЛОВЕКА
Keywords:
CDH1 gene, mRNA gene,Abstract
It is established that mRNA of CDH1 gene of human is been reacted 29 entergenic miRNAs and 15 intronic miRNAs. Value of score and binding free energy between miRNA and 3'-untranslated region of mRNA of CDH1 gene were calculated. Binding particularities of examined miRNAs with this region of mRNA of CDH1 gene were revealed.References
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2. Boonstra J.J., van Marion R., Tilanus H.W., Dinjens W.N. Functional polymorphisms associated with diseasefree
survival in resected carcinoma of the esophagus. J. Gastrointest. Surg., 2011, V.15, P.48-56.
3. Cho I.J., Kim Y.W., Han C.Y. et al. E-cadherin antagonizes transforming growth factor ОІ1 gene induction in
hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation. Hepatology, 2010, V.52, P.2053-2064.
4. Mao Z., Ma X., Rong Y. et al. Connective tissue growth factor enhances the migration of gastric cancer
through downregulation of E-cadherin via the NF-ОєB pathway.Cancer Sci., 2011, V.102, P.104-110.
5. Sterlacci W., Fiegl M., Hilbe W. et al. Deregulation of p27 and cyclin D1/D3 control over mitosis is associated
with unfavorable prognosis in non-small cell lung cancer, as determined in 405 operated patients. J. Thorac. Oncol., 2010, V.5, P.1325-1336.
6. Bagnyukova T.V., Pogribny I.P., Chekhun V.F. microRNAs in normal and cancer cells: a new class of gene expression regulators. Experimental Oncol., 2006, V.28, P.263-269.
7. Almeida M.I., Reis R.M., Calin G.A. MYC-microRNA-9-metastasis connection in breast cancer. Cell Research, 2010, V.20, P.603-604.
8. Le X.L., Merchant O., Bast R.C., Calin G.F. The roles of microRNAs in the cancer invasion-metastasis cascade. Cancer Microenviron, 2010, V.23, P.137-147.
9. Xu J. , Li C.-X. , Li Y.-S. et.al. MiRNA–miRNA synergistic network: construction via co-regulating functional
modules and disease miRNA topological featuresNucleic Acids Research, 2011, V. 39,P. 825–836
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