Investigations of LPS endotoxin elimination in the flowing column conditions with the sorbent on the basis of carbonized rice husk
Keywords:
phytoextract, carbonized rice husk, sorbent, antimicrobial properties, functionalizathion, herbal plants, toxic infections, purulent inflammation processesAbstract
This research work is devoted to study lipopolysaccharide (LPS) detoxication on the basis of its sorption by nanostructured carbonized rice husk from biological liquids.During experimental tests it is established that in the flowing column conditions with carbonized rice husk the elimination of LPS endotoxin from biological liquids shows 98%.References
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Chromatogr. B Biomed. Sci. Appl. – 2007. – Vol. 693. - P. 79-91.
2 Гусаров Д.А. Способы очистки биофармацевтических белков от эндотоксинов клеточной стенки //
Биофармацевтический журнал. – 2009. – Т. 17 – № 3. – С. 10-17.
3 Mansurov Z.A., Zhubanova A.A., Digel I., Artmann G. Artmann A., Savitskaja I.S., Kistaubaeva A.S., Kozhalakova A.A. The
sorbtion of LPS toxic shock by nanoparticles on base of carbonizated vegetable raw materials // Carbon’08. - Nagano (Japan), 2008. – P.
12-15.
4 Petsch D., Anspach F.B. Endotoxin removal from protein solutions // J. Biotechnol. – 2000. – Vol. 76, № 2-3. – P. 97-119.
5 Hirayama C., Sakata M., Nakamura M., Ihara H., Kunitake M., Todokoro M. Preparation of poly(epsilon-lysine) adsorbents
and application to selective removal of lipopolysaccharides // J. Chromatogr. B Biomed. Sci. Appl. – 1999. - Vol. 721. - P. 187-195.
6 Hirayama C., Sakata M. Chromatographic removal of endotoxin from protein solutions by polymer particles // J. Chromatogr.
B Analyt. Technol. Biomed. Life Sci. – 2002. – Vol. 781, №1-2. – P. 419-432.
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