Study of the hormonal status of the pituitary-gonadal system in adolescent girls with reproductive disorders
DOI:
https://doi.org/10.26577//eb.2020.v83.i2.12Abstract
The puberty is one of the most difficult periods of the formation of the body. It is this period that is characterized by morphological and functional rearrangements. Under the influence of sex hormones secreted by the body in large quantities, the neuroendocrine system is rearranged. Heavy training loads, information overstrain, emotional stress, disturbance of sleep and wakefulness, adverse environmental influences contribute to a negative shift of physiological parameters from normal. A prolonged stay in such conditions leads to a deviation of physiological functions from the norm, and, as a result, to a violation of the functions of the reproductive organs. The aim of this work was to study pituitary (LH, FSH), sex (testosterone, estradiol) and thyroid-stimulating (TSH) hormones in the blood of schoolgirls in the city of Almaty. Research was conducted at the Centre of Molecular Medicine. A comprehensive analysis of hormones was performed in 70 girls of the city of Almaty aged 12 to 16 years. The results were obtained by ELISA. The mean norm values of FSH hormones were found to be 5.08 ± 0.19 IU / L, LH 5.14 ± 0.35 IU / L, LH / FSH 1.22 ± 0.03, Estradiol 13.6 - 190.4 pg / ml, testosterone 0.7 ± 0.07 ng / ml, TSH 2.06 ± 0.11 μI / l. Most of the examined schoolgirls showed deviations from the norm in the direction of increasing hormone and on average are LH 12.1 ± 0.53 IU / L, LH / FSH 2.52 ± 0.17, estradiol 395 ± 0.28 pg / ml, testosterone 2.99 ± 0.12 ng / ml, 3.7 ± 0.02 μMU / L. Identified deviations may be associated with adverse environmental conditions, since Almaty is on the list of the most polluted cities among the CIS countries.
Key words: reproductive system, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, testosterone, thyroid-stimulating hormone (TSH), ecology.
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47. Andreeva V.O. Sostoıanıe reprodýktıvnoı sıstemy devochek-podrostkov prı nervnoı anoreksıı. URL: https://www.dissercat.com/content/sostoyanie-reproduktivnoi-sistemy-devochek-podrostkov-pri-nervnoi-anoreksii (Data obraenııa: 3.04.2020)
2. Dedov I.I., Semicheva T.V., Peterkova V.A. (2002). Polovoe razvitie detei: norma I patologiia. – M: Meditsina. – S. 50–66.
3. Filgus T.A., Rudzevich A.YU., Kukarskaya I.I. (2017). Yuvenilnye krovotecheniya v sovremennoj populyacii detej i podrostkov // Mezhdunarodnyj zhurnal prikladnyh i fundamentalnyh issledovanij. – № 6-5. – S. 887-890.
4. Korsynskii A.A., Gavrilova L.V., Ilin A.G., i dr. (2002). Slyjba ohrany zdorovıa materi i rebenka v 2002 gody. – M. – 83 s.
5. Cameron J.L. (2003). Stress and Reproduction // Encyclopedia of Hormones. – USA: Academic Press. – P. 433–438.
6. Yvarova E.V. (2003). Reprodyktivnoe zdorove devochek podrostkovogo vozrasta // Rossiiskii vestnik perınatologii i pediatrii. – № 5. – S.8– 9.
7. Shilin D.E. (1999). Sindrom izolirovannogo pybarhe y devochek / / Rykovodstvo dlia endokrinologov. – M. – S. 1–19.
8. Gendernaya statistika Kazahstana // MNE RK komitet po statistike. URL: http://gender.stat.gov.kz/ru (data obrashcheniya: 15.01.2019.)
9. Country comparison: birth rate (2018) // The world factbook
URL: https://www.cia.gov/library/publications/the-world-factbook/fields/345rank.html (data obrashcheniya: 26.01.2020.)
10. Anartaeva M.Y. (2004). Rol sotsialno-gigienicheskih faktorov, vlııaıyıh na reprodyktivnoe zdorove jenin Iyjno-Kazahstanskoi oblasti // Med. Jyrn.Kazahstana. – №1. – S. 7-9.
11. Caserta D, Maranghi L, Mantovani A, Marci R, Maranghi F, Moscarini M. (2008). Impact of endocrine disruptor chemicals in gynaecology. – Human Reproduction Update. – Vol. 14(1). – P. 59-72.
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13. Ekologicheskaya obstanovka v Almaty podoshla k kriticheskomu urovnyu (2017) // Moskovskij komsomelec Kazahstan. URL:http://mk-kz.kz/articles/2017/11/15/ekologicheskaya-obstanovka-v-almaty-podoshla-k-kriticheskomu-urovnyu.htm (data obrashcheniya: 20.05.2018.)
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16. Caserta D, Maranghi L, Mantovani A, Marci R, Maranghi F, Moscarini M. (2008). Impact of endocrine disruptor chemicals in gynaecology. – Human Reproduction Update. – Vol. 14, №1. – P. 59–72.
17. Caranaugh D. (1999). Menstrual irregularities in athletic women may be predictable based on protraining menses / D. Caranaugh, A. Kanonchoff, R. Bartels // The Journal of Sports Medicine and Physical Fitness. – Vol. 29, № 12. – P. 163–169.
18. Vabre P, Gatimel N, Moreau J et al. (2017). Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data. – Environmental Health. – P. 16–37.
19. Betts K.S. (2008). Unwellcome guest // Environ. Health Persp. – Vol. 116. – P. 363-366.
20. Bucher J.R. Bisphenol A. (2009). Where to now? – Environ. Health Persp. – Vol. 117. –P. 96-97.
21. Sergeev O.V., Revich. B., Saharov I.V. i dr. (2008). Soderzhanie PHDD/ PHDF na territorii zavoda, v okruzhayushchej srede i produktah pitaniya CHapaevska posle polnoj ostanovki zavoda, vypuskavshego pesticidy, i 10 let reabilitacionnyh programm // Vestnik Ros. VMA. – № 3, pril. 2, ch. 1. – S. 90.
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23. GMO // The Village.ru URL: https://www.the-village.ru/village/food/true-or-false-food/239621-gmo (Data obraenııa: 12.01.2020)
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25. Losey J.E., Rayor L.S., Carter M.E. (1999) // Nature. – P.214.
26. World Scientists Statement (2000). Supplementary Information of the Hazards of Genetic Engineering Biotechnology. – Third World Network.
27. Netherwood T., Bowden R., Harrison P., O'Donnell A.G., Parker D.S., Gilbert H.J.Gene (1999) // Appl Environ Microbiol. – Vol. 65(11). – P. 5139.
28. Ermakova I.V. (2009). Vliyanie soi s genom EPSPS CP4 na fiziologicheskoe sostoyanie i reproduktivnye funkcii krys v pervyh dvuh // Sovremennye problemy nauki i obrazovaniya. – № 5.
29. V Evrope zavershılı eksperıment vlııanııa GMO prodýktov na krysah. URL: https://delo.ua/econonomyandpoliticsinukraine/v-evrope-zavershili-eksperiment-gmo-produktov-na-krysah-185527/ (Data obraenııa: 7.02.2020)
30. A. Karımova GMO – vsemý golova. URL: https://www.kommersant.ru/doc/1519871 (Data obraenııa: 18.12.2019)
31. Druckmann R., Druckmann M.A. (2005). Progesterone and immunology of pregnancy // J. Steroid Biochem Mol.Biol. – Vol. 5, No 97. – P. 389-96.
32. Bohring C., Krause W. (2003). Immune infertility: towards a better understanding a sperm (auto)-immunity // Human Reproduction. — Vol. 18, № 5. — P. 915-924.
33. Ericson GF.(2000). Ovarian anatomy and physiology. Menopause. Biology and pathobiology / Ed Lobo RA, Kelsey J, Marcus R. – San Diego: Academic Press. – P. 13-32.
34. N.S.Motuzko, YU.I.Nikitin (2002). Fiziologiya gipotalamo-gipofizarno-ovaral'noj sistemy: ucheb.-metod. posobie. – Vitebsk: VitGAVM. – S. 9.
35. Ericson GF. (2000). Menopause. Biology and pathobiology / Ed Lobo RA, Kelsey J, Marcus R. – San Diego: Academic Press. – P. 12.
36. Jerome F. Strauss Yen and Jaffe’s Reproductive Endocrinology: Physiology, Pathology, Pathophysiology and Clinical Management. – 6th ed. – Saunders Elsevier, 2009. – 803-814 р.
37. Bochkareva N.V. (2003). Voprosy ginekologii i akusherstva // Voprosy ginekologii, akusherstva i perinatologii. – T. 2, №1. – S. 57-60.
38. Akanov A.A. (2008). Ocenka reproduktivnogo zdorov'ya zhenshchin v Respublike Kazahstan // Densaulyқ saқtaudy damytu zhurnaly. – T. 4, №1. – S. 63-65.
39. JoAnn V. Pinkerton , MD, University of Virginia Health System URL:https://www.msdmanuals.com/ru/ (Data obraenııa: 18.12.2019)
40. Estradıol. Medıtsınskıı tsentr Bıomedıka Plıýs URL: https://biomedica.by/estradiol.html (Data obraenııa: 18.12.2019)
41. Manusharova R.A., CHerkezova E.I. (2008). Ginekologicheskaya endokrinologiya: Rukovodstvo dlya vrachej. – M.: MIA.
42. Parijskaya E.N., Erofeev N.P. (2013). Fiziologiya endokrinnoj sistemy. – SPb.: SpecLit. – 80 s.
43. Tsentr EKO URL: https://www.rf-ivf.ru/konsultatsii-spetsialistov/endokrinologiya/482-fsg-i-lg-sootnoshenie-i-norma.html (Data obraenııa: 18.03.2020)
44. Estradıol // Vıkıpedıı — svobodnaıa entsıklopedııa URL: https://ru.wikipedia.org/wiki/%D0%AD%D1%81%D1%82%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D1%8B (Data obraenııa: 18.03.2020)
45. Belgorodsky A., et al. (2009). Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence // Horm Res. — Vol. 72(б). — Р.321-330.
46. Charlier T.D., et al. (2010). Diversity of mechanisms involved in aromatase regulation and estrogen action in the brain // Biochim Biophys Acta. — Vol. 1800(10). — Р. 1094-1105.
47. Andreeva V.O. Sostoıanıe reprodýktıvnoı sıstemy devochek-podrostkov prı nervnoı anoreksıı. URL: https://www.dissercat.com/content/sostoyanie-reproduktivnoi-sistemy-devochek-podrostkov-pri-nervnoi-anoreksii (Data obraenııa: 3.04.2020)
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Published
2020-07-13
How to Cite
Deyeva, O. A., Ledyaeva, S. S., Kadirbaeva, D. S., & Srayilova, G. T. (2020). Study of the hormonal status of the pituitary-gonadal system in adolescent girls with reproductive disorders. Experimental Biology, 83(2), 114–124. https://doi.org/10.26577//eb.2020.v83.i2.12
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HUMAN AND ANIMAL PHYSIOLOGY
