ИСПОЛЬЗОВАНИЕ ШКАЛЫ ГРИМАС КРЫСЫ В ИССЛЕДОВАНИЯХ БОЛИ
DOI:
https://doi.org/10.26577/eb.2024.v98.i1.013Ключевые слова:
шкала гримасы крыс, боль, мигрень, преклинические исследованияАннотация
С момента своего внедрения в 2011 году, шкала гримасы крыс стала ценным инструментом для оценки боли в преклинических исследованиях. В нашей статье мы предоставляем обзор разнообразных исследований, в которых данный метод применялся в хирургических и послеоперационных моделях боли, воспалительных моделях боли, ортодонтических и орофациальных моделях боли, невропатических моделях боли и других. Кроме того, мы представляем результаты оценки боли у крыс с нитроглицерин-индуцированной мигренью. Несмотря на то, что шкала охватывает четыре функциональных юнита, наши выводы указывают на то, что в модели мигрени предпочтительнее использовать орбитальное сужение, как функциональный юнит, наилучшим образом соответствующих особенностям данной модели. Интересным направлением является перспектива использования технологий искусственного интеллекта для автоматического распознавания болевой гримасы и анализа данных. Этот инновационный подход обещает существенно сократить временные и ресурсные затраты на оценку изображений, а также повысить точность оценок, исключив субъективность, связанную с оценками, проводимыми человеком.
Библиографические ссылки
Darwin C. The expression of emotions in animals and man // London: Murray. – 1872. - Vol. 11. - P. 1872.
Langford D. J., Bailey A. L., Chanda M. L., Clarke S. E., Drummond T. E., Echols S., Glick S., Ingrao J., Klassen-Ross T., LaCroix-Fralish M.L., Matsumiya L., Mogil J. S. Coding of facial expressions of pain in the laboratory mouse // Nature methods. – 2010. - Vol. 7. - P. 447-449.
Sotocina S. G., Sorge R. E., Zaloum A., Tuttle A. H., Martin L. J., Wieskopf J. S., Mapplebeck J.C., Wei P., Zhan S., Zhang S., Mogil J. S. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions // Molecular pain. – 2011. - Vol. 7. - P. 1744-8069.
Chi H., Kawano T., Tamura, T., Iwata, H., Takahashi, Y., Eguchi, S., Yamazaki F., Kumagai N., Yokoyama, M. Postoperative pain impairs subsequent performance on a spatial memory task via effects on N-methyl-D-aspartate receptor in aged rats // Life sciences. -2103. - Vol. 93. - P. 986-993.
Kawano T., Eguchi S., Iwata H., Yamanaka D., Tateiwa H., Locatelli F. M., Yokoyama M. Effects and underlying mechanisms of endotoxemia on post-incisional pain in rats // Life science. – 2016. - Vol. 148. - P. 145-153.
Waite M. E., Tomkovich A., Quinn T. L., Schumann A. P., Dewberry L., Totsch S. K., Sorge R. E. Efficacy of common analgesics for postsurgical pain in rats //Journal of the American Association for Laboratory Animal Science. – 2015. - Vol. 54. - P. 420-425.
Thomas A., Miller A., Roughan J., Malik A., Haylor K., Sandersen C., Flecknell P., Leach M. Efficacy of intrathecal morphine in a model of surgical pain in rats // PLoS One. – 2016. - Vol. 11. - P. e0163909.
Gao Z., Cui F., Cao X., Wang D., Li X., Li T. Local infiltration of the surgical wounds with levobupivacaine, dexibuprofen, and norepinephrine to reduce postoperative pain: A randomized, vehicle–controlled, and preclinical study // Biomedicine & Pharmacotherapy. – 2017. - Vol. 92. - P. 459-467.
Guo P., Hu S. P. Thalidomide alleviates postoperative pain and spatial memory deficit in aged rats // Biomedicine & Pharmacotherapy. – 2017. - Vol. 95. - P. 583-588.
Klune C. B., Larkin A. E., Leung V. S., Pang D. Comparing the rat grimace scale and a composite behaviour score in rats // PloS one. – 2019. - Vol. 14. - P. e0209467.
Koyama T., Kawano T., Iwata H., Aoyama B., Eguchi S., Nishigaki A., Yokoyama, M. Acute postoperative pain exacerbates neuroinflammation and related delirium-like cognitive dysfunction in rats // Journal of anesthesia. – 2019. - Vol. 33. - P. 482-486.
Oliver V., De Rantere D., Ritchie R., Chisholm J., Hecker K. G., Pang D. S. Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score // PLoS One. – 2014. - Vol. 9. - P. e97882.
De Rantere D., Schuster C. J., Reimer, J. N., Pang, D. S. The relationship between the Rat Grimace Scale and mechanical hypersensitivity testing in three experimental pain models // European Journal of Pain. – 2016. - Vol. 20(3). - P. 417-426.
Kawano T., Takahashi T., Iwata H., Morikawa A., Imori S., Waki, S., Tamura T., Yamazaki F., Eguchi S., Kumagai N., Yokoyama M. Effects of ketoprofen for prevention of postoperative cognitive dysfunction in aged rats // Journal of anesthesia. – 2014. - Vol. 28. - P. 932-936.
Yamanaka D., Kawano T., Nishigaki A., Aoyama B., Tateiwa H., Shigematsu-Locatelli M., Locatelli F.M., Yokoyama, M. The preventive effects of dexmedetomidine on endotoxin-induced exacerbated post-incisional pain in rats // Journal of anesthesia. – 2017. - Vol. 31. - P. 664-671.
Schneider L. E., Henley K. Y., Turner O. A., Pat B., Niedzielko T. L., Floyd C. L. Application of the rat grimace scale as a marker of supraspinal pain sensation after cervical spinal cord injury // Journal of neurotrauma. – 2017. - Vol. 34. - P. 2982-2993.
VS H., Krishnan L. K., Abelson K. S. A novel technique to develop thoracic spinal laminectomy and a methodology to assess the functionality and welfare of the contusion spinal cord injury (SCI) rat model // Plos one. – 2019. - Vol. 14. - P. e0219001.
Harikrishnan V. S., Palekkodan H., Fasaludeen A., Krishnan L. K., Abelson K. S. Refinement of the spinal cord injury rat model and validation of its applicability as a model for memory loss and chronic pain // Heliyon. – 2021. - Vol. 7.
Pal A., Park H., Ramamurthy A., Asan A. S., Bethea T., Johnkutty M., Carmel J. B. Spinal cord associative plasticity improves forelimb sensorimotor function after cervical injury // Brain. – 2022. - Vol. 145. - P. 4531-4544.
Semita I. N., Utomo D. N., Suroto H., Sudiana I. K., Gandi P. The mechanism of human neural stem cell secretomes improves neuropathic pain and locomotor function in spinal cord injury rat models: Through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities // The Korean Journal of Pain. – 2023. - Vol. 36. - P. 72-83.
Tsaousi G., Pourzitaki C., Kapanidis K., Mavrantoni E., Kapoukranidou D., Kouvelas D. Modulation of nociception and pain-evoked neurobehavioral responses by levetiracetam in a craniotomy pain model // Behavioural Brain Research. – 2022. - Vol. 420. - P. 113728.
Asgar J., Zhang Y., Saloman J. L., Wang S., Chung M. K., Ro J. Y. The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats // Neuroscience. – 2015. - Vol. 310. - P. 206-215.
Leung V., Zhang E., Pang D. S. Real-time application of the Rat Grimace Scale as a welfare refinement in laboratory rats // Scientific reports. – 2016. - Vol. 6. - P. 31667.
Leung V. S., Benoit-Biancamano M. O., Pang D. S. Performance of behavioral assays: The Rat Grimace Scale, burrowing activity and a composite behavior score to identify visceral pain in an acute and chronic colitis model // Pain Reports. - 2019. - Vol. 4.
Nurhapsari A., Cilmiaty R., Prayitno A., Purwanto B., Soetrisno S. The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study // Clinical, Cosmetic and Investigational Dentistry. – 2023. – P. 109-119.
Lovrenčić L., Matak I., Lacković Z. Association of intranasal and neurogenic dural inflammation in experimental acute rhinosinusitis // Frontiers in Pharmacology. – 2020. - Vol. 11. - P. 586037.
Liao L., Long H., Zhang L., Chen H., Zhou Y., Ye N., Lai W. Evaluation of pain in rats through facial expression following experimental tooth movement // European journal of oral sciences. – 2014. - Vol. 122, - P. 121-124.
Long H., Liao L., Gao M., Ma W., Zhou Y., Jian F., Wang Y., Lai W. Periodontal CGRP contributes to orofacial pain following experimental tooth movement in rats // Neuropeptides/ - 2015. - Vol. 52. - P. 31-37.
Gao M., Long H., Ma, W., Liao L., Yang X., Zhou Y., Shan D., Huang R., Jian F., Lai, W. The role of periodontal ASIC3 in orofacial pain induced by experimental tooth movement in rats // European journal of orthodontics. – 2016. - Vol. 38. - P. 577-583.
Guo R., Zhou Y., Long H., Shan D., Wen J., Hu H., Yang H., Wu Z., Lai W. Transient receptor potential Vanilloid 1-based gene therapy alleviates orthodontic pain in rats // International journal of oral science. – 2019. - Vol. 11. - P. 11.
Sperry M. M., Yu Y. H., Welch R. L., Granquist E. J., Winkelstein B. A. Grading facial expression is a sensitive means to detect grimace differences in orofacial pain in a rat model // Scientific Reports. – 2018. - Vol. 8. - P. 13894.
Thammanichanon P., Kaewpitak A., Binlateh T., Pavasant P., Leethanakul C. Varied temporal expression patterns of trigeminal TRPA1 and TRPV1 and the neuropeptide CGRP during orthodontic force-induced pain // Archives of Oral Biology. – 2021. - Vol. 128. - P. 105170.
Long H., Liao L., Zhou Y., Shan D., Gao M., Huang R., Yang X., Lai W. A novel technique of delivering viral vectors to trigeminal ganglia in rats // European Journal of Oral Sciences. – 2017. - Vol. 125. - P. 1-7.
Philips B. H., Weisshaar C. L., Winkelstein B. A. Use of the rat grimace scale to evaluate neuropathic pain in a model of cervical radiculopathy // Comparative medicine. – 2017. - Vol. 67. - P. 34-42.
Akintola T., Raver C., Studlack P., Uddin O., Masri R., Keller A. The grimace scale reliably assesses chronic pain in a rodent model of trigeminal neuropathic pain // Neurobiology of Pain. – 2017. - Vol. 2. - P.13-17.
Goder D., Giladi S., Furer A., Zilberman M. Bupivacaine‐eluting soy protein structures for controlled release and localized pain relief: An in vitro and in vivo study // Journal of Biomedical Materials Research Part A. - 2021. - Vol. 109. - P. 1681-1692.
Goder D., Eshkol-Yogev I., Matsliah L., Lemberger M., Harlev M., Furer A., Zilberman M., Egozi D. In vivo study of the efficacy of bupivacaine-eluting novel soy protein wound dressings in a rat burn model // Burns. – 2022. - Vol. 48. - P. 623-632.
Saine L., Hélie P., Vachon P. Effects of fentanyl on pain and motor behaviors following a collagenase-induced intracerebral hemorrhage in rats // Journal of Pain Research. – 2016. -P. 1039-1048.
Wilkinson C. M., Kalisvaart A. C., Kung T. F., Maisey D. R., Klahr A. C., Dickson C. T., Colbourne F. The collagenase model of intracerebral hemorrhage in awake, freely moving animals: The effects of isoflurane // Brain Research. – 2020. - Vol. 1728. - P. 146593.
George R. P., Howarth G. S., Whittaker, A. L. Use of the rat grimace scale to evaluate visceral pain in a model of chemotherapy-induced mucositis // Animals. – 2019. - Vol. 9. - P. 678.
Nagakura Y., Miwa M., Yoshida M., Miura R., Tanei S., Tsuji M., Takeda H. Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia // European Journal of Pharmacology. – 2019. - Vol. 864. - P. 172716.
Tanei S., Miwa M., Yoshida M., Miura R., Nagakura Y. The method simulating spontaneous pain in patients with nociplastic pain using rats with fibromyalgia-like condition // MethodsX. – 2020. - Vol. 7. - P. 100826.
Uddin O., Studlack P. E., Parihar S., Keledjian K., Cruz A., Farooq T., Shin N., Gerzanich V., Simard J.M., Keller A. Chronic pain after blast-induced traumatic brain injury in awake rats // Neurobiology of Pain. – 2019. - Vol. 6. – P. 100030.
Kudsi S. Q., de David Antoniazzi C. T., Camponogara C., Meira G. M., de Amorim Ferreira M., da Silva A. M., Trevisan G. Topical application of a TRPA1 antagonist reduced nociception and inflammation in a model of traumatic muscle injury in rats // Inflammopharmacology. – 2023. -P. 1-14.
Reed W. R., Little J. W., Lima C. R., Sorge R. E., Yarar-Fisher C., Eraslan M., Hurt C.P., Ness T.J., Gu J.G., Martins D.F., Li P. Spinal mobilization prevents NGF-induced trunk mechanical hyperalgesia and attenuates expression of CGRP // Frontiers in Neuroscience. – 2020. -Vol. 14. - P. 385.
Liu W., Jiang H., Liu X., Hu S., Li H., Feng Y., Ke J., Long X. Melatonin Abates TMJOA chronic pain by MT2R in trigeminal ganglion neurons // Journal of Dental Research. – 2022. - Vol. 101. - P. 111-119.
Chen D., Ren Y., Jin J., Liu S., Zhan X., Li X., Liang R., Ding, Z. Pingchong Jiangni recipe through nerve growth factor/transient receptor potential vanilloid 1 signaling pathway to relieve pain in endometriosis model rats // Journal of Ethnopharmacology. – 2024. - Vol. 318. - P.116940.
Ponterotto J. G., Ruckdeschel D. E. An overview of coefficient alpha and a reliability matrix for estimating adequacy of internal consistency coefficients with psychological research measures// Perceptual and motor skills. – 2007. -Vol. 105. - P. 997-1014.
Harris H. M., Carpenter J. M., Black J. R., Smitherman T. A., Sufka K. J. The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification// Journal of Neuroscience Methods. – 2017. - Vol. 284. - P. 63-70.
Yamamoto K., Tatsutani S., Ishida T. Detection of nausea-like response in rats by monitoring facial expression // Frontiers in pharmacology. – 2014. - Vol. 7. - P. 534.
Sorge R. E., Martin L. J., Isbester K. A., Sotocinal S. G., Rosen S., Tuttle A. H., Wieskopf J.S., Acland E.L., Dokova A., Kadoura B., Mogil J. S. Olfactory exposure to males, including men, causes stress and related analgesia in rodents // Nature methods. – 2014. - Vol. 11. - P. 629-632.
Tuttle A. H., Molinaro M. J., Jethwa J. F., Sotocinal S. G., Prieto J. C., Styner M. A., Mogil J.S., Zylka M. J. A deep neural network to assess spontaneous pain from mouse facial expressions // Molecular pain. – 2018. – Vol.14. – P. 1744806918763658.
