Кишечный микробиом и болезнь Альцгеймера

  • Sh. Askarova
  • A. Kushugulova
  • A. Kaiyrlykyzy
  • A. Tsoy
  • A. Masoud
  • F. Olzhayev

Аннотация

Болезнь Альцгеймера является хроническим неизлечимым нейродегенеративным заболеванием и наиболее распространенной формой возрастной деменции. На развитие этой патологии у пожилых людей влияют различные факторы, такие как образ жизни, уровень стресса, генетическая предрасположенность, хронические заболевания, а также факторы окружающей среды. Одним из факторов, влияющих на состояние здоровья человека, и привлекающим все большее внимание ученых за последние 15 лет является кишечный микробиом. Микробиом кишечника - это сообщество микроорганизмов, колонизирующих желудочно-кишечный тракт и оказывающих огромное влияние на физиологию человека в норме и патологии. В последние годы накоплена значительная информация о том, что состав кишечной микрофлоры изменяется при различных патологических состояниях организма человека, включая нейродегенеративные заболевания. В связи с вышесказанным, в настоящей обзорной статье обсуждается связь кишечного микробиома и головного мозга и роль микроорганизмов, населяющих гастроэнтеральный тракт в развитии болезни Альцгеймера. 
Ключевые слова: головной мозг, нейродегенерация, болезнь Альцгеймера, бета-амилоид, кишечник, кишечный микробиом.

Литература

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Опубликована
2019-01-31
Как цитировать
ASKAROVA, Sh. et al. Кишечный микробиом и болезнь Альцгеймера. Experimental Biology, [S.l.], v. 77, n. 4, p. 74-85, jan. 2019. ISSN 2617-7498. Доступно на: <http://bb.kaznu.kz/index.php/biology/article/view/1365>. Дата доступа: 22 mar. 2019

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