Biotechnology for promising secondary metabolites of cyanobacteria
Keywords:
cyanobacteria, Microcystis aeruginosa, Microcystis aeruginosa Kutz, Nostoc rivulare, toxins, hepatotoxins, cytotoxicity, microcystins,Abstract
The review describes the available diversity toxins of cyanobacteria and their prospects for biotechnology. Particular attention is paid to types of toxins, representing on the one hand a danger to humans and animals, and at the same time interesting for medicine and biotechnology as a source of various pharmaceuticals.References
1 Волошко Л.Н., Плющ А.В., Титова Н.Н. Токсины Цианобактерий (Cyanobacteia, Cyanophyta) // Альгология. – 2008. – Т. – 18. - №1. – С.3-21.
2 Шарма Н.К. Сингх С. Влияние Токсинов Nostoc Muscorum Ag. Exborn. Et Flah. На Верхние Дыхательные Пути Мышей //Algologia. – 2008. – T. – 18. - №1. – С.29-36.
3 Кокшарова О.А. Применение Методов Молекулярной Генетики и Микробиологии в Экологии и Биотехнологии Цианобактерий // Микробиология. – 2010. – Т.79. - № 6. – С.734–747.
4 Hrouzek P., Kuzma M., Cerny J. The Cyanobacterial Cyclic Lipopeptides Puwainaphycins F/G Are Inducing Necrosis via Cell Membrane Permeabilization andSubsequent Unusual Actin Relocalization // Chem. Res. Toxicol. – 2012. – V.25. – P. 1203−1211.
5 Wiesner C., Kopecky J., Pfluegerb M. Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti Inflammatory and Wound-Healing Promoting Metabolites // Drug Metabolism Letters. – 2007. – V.1. -№ 3. – P. 1-7.
6 Thummajitsakul S. Antibacterial activity of crude extracts of cyanobacteria Phormidium and Microcoleus species //African Journal of Microbiology Research. – 2012. – V.6(10). – С. 2574-2579.
7 Hrouzek P., Kuzma M., Сerny J. The Cyanobacterial Cyclic Lipopeptides Puwainaphycins F/G Are Inducing Necrosis via Cell Membrane Permeabilization and Subsequent Unusual Actin Relocalization // Chem. Res. Toxicol. - 2012. – V.25. – P. 1203−1211.
8 Vacek J., Hrbac J., Kopecky J. Cytotoxicity and Pro-Apoptotic Activity of 2,2´-Bis[4,5-bis(4-hydroxybenzyl)-2-(4- hydroxyphenyl)cyclopent-4-en-1,3-dione],a Phenolic Cyclopentenedione Isolated from the Cyanobacterium Strain Nostoc sp. str. Lukesova 27/97 //Molecules. – 2011. – V.16. – P. 4254-4263.
9 Voloshko L., Kopeckyc J., Safronova T. Toxins and other bioactive compounds produced by cyanobacteria in Lake Ladoga //Estonian Journal of Ecology. – 2008. – V.57(2). – P. 100-110.
10 Hisem D., Hrouzek P., Tomek P. Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina. – Elsevier Ltd. All rights reserved, 2010. – P. 1-8.
11 Wiesner C., Kopecky J., Pfluegerb M. Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti-Inflammatory and Wound-Healing Promoting Metabolites // Drug Metabolism Letters. – 2007. – V.1. -№.3. – P. 1-7.
12 Klejdus B., Kopecky J., Benesova L., Vaceka J. Solid-phase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species // Journal of Chromatography A. – 2009. – V. 1216. – P.763-771.
2 Шарма Н.К. Сингх С. Влияние Токсинов Nostoc Muscorum Ag. Exborn. Et Flah. На Верхние Дыхательные Пути Мышей //Algologia. – 2008. – T. – 18. - №1. – С.29-36.
3 Кокшарова О.А. Применение Методов Молекулярной Генетики и Микробиологии в Экологии и Биотехнологии Цианобактерий // Микробиология. – 2010. – Т.79. - № 6. – С.734–747.
4 Hrouzek P., Kuzma M., Cerny J. The Cyanobacterial Cyclic Lipopeptides Puwainaphycins F/G Are Inducing Necrosis via Cell Membrane Permeabilization andSubsequent Unusual Actin Relocalization // Chem. Res. Toxicol. – 2012. – V.25. – P. 1203−1211.
5 Wiesner C., Kopecky J., Pfluegerb M. Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti Inflammatory and Wound-Healing Promoting Metabolites // Drug Metabolism Letters. – 2007. – V.1. -№ 3. – P. 1-7.
6 Thummajitsakul S. Antibacterial activity of crude extracts of cyanobacteria Phormidium and Microcoleus species //African Journal of Microbiology Research. – 2012. – V.6(10). – С. 2574-2579.
7 Hrouzek P., Kuzma M., Сerny J. The Cyanobacterial Cyclic Lipopeptides Puwainaphycins F/G Are Inducing Necrosis via Cell Membrane Permeabilization and Subsequent Unusual Actin Relocalization // Chem. Res. Toxicol. - 2012. – V.25. – P. 1203−1211.
8 Vacek J., Hrbac J., Kopecky J. Cytotoxicity and Pro-Apoptotic Activity of 2,2´-Bis[4,5-bis(4-hydroxybenzyl)-2-(4- hydroxyphenyl)cyclopent-4-en-1,3-dione],a Phenolic Cyclopentenedione Isolated from the Cyanobacterium Strain Nostoc sp. str. Lukesova 27/97 //Molecules. – 2011. – V.16. – P. 4254-4263.
9 Voloshko L., Kopeckyc J., Safronova T. Toxins and other bioactive compounds produced by cyanobacteria in Lake Ladoga //Estonian Journal of Ecology. – 2008. – V.57(2). – P. 100-110.
10 Hisem D., Hrouzek P., Tomek P. Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina. – Elsevier Ltd. All rights reserved, 2010. – P. 1-8.
11 Wiesner C., Kopecky J., Pfluegerb M. Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti-Inflammatory and Wound-Healing Promoting Metabolites // Drug Metabolism Letters. – 2007. – V.1. -№.3. – P. 1-7.
12 Klejdus B., Kopecky J., Benesova L., Vaceka J. Solid-phase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species // Journal of Chromatography A. – 2009. – V. 1216. – P.763-771.
Downloads
Issue
Section
BIOTECHNOLOGY
