Антимутагенная активность биологически активных веществ, продуцируемых дикультурой микроводорослей А.flos-aquae х A. аrnoldii

S. Zh. Kolumbayeva; A. V. Lovinskaya; S. A. Dzhokebaeva; N. S. Shynbergenova

Authors

S. Zh. Kolumbayeva Казахский национальный университет им. аль-Фараби, г. Алматы, Казахстан
A. V. Lovinskaya Казахский национальный университет им. аль-Фараби, г. Алматы, Казахстан
S. A. Dzhokebaeva Казахский национальный университет им. аль-Фараби, г. Алматы, Казахстан
N. S. Shynbergenova Казахский национальный университет им. аль-Фараби, г. Алматы, Казахстан

Keywords:

biologically active substances, microalgae, antimutagenic activity.

Abstract

It was studied mutagenic and anti-mutagenic properties of biologically active substances (BAS) from mixed culture of microalgae A.flos-aquae x A.Arnoldii. Our findings revealed that dose of 0.1 mg/kg of BAS did not have mutagenic effects in Mammalian Bone Marrow Chromosome Aberration Test. Unsymmetrical dimethylhydrazine (1.1-DMH) both in acute and subacute exposure significantly increased the induction of chromosomal mutations in bone marrow cells of experimental animals compared to intact. After the combined action of biologically active substances with unsymmetrical dimethylhydrazine there was a significant modification of the mutagenic effect of 1.1-DMH. Mutagenic effect of 1.1-DMH was increased. The results indicate the presence of antimutagenic activity of biologically active substances from mixed culture of microalgae A.flos-aquae x A.Arnoldiif.