ХАРАКТЕРИСТИКИ СВЯЗЫВАНИЯ МЕЖГЕННЫХ, ИНТРОННЫХ И ЭКЗОННЫХ miRNA С mRNA ГЕНОВ УЧАСТВУЮЩИХ В ОНКОГЕНЕЗЕ

Abstract

Interaction of 784 intergenic miRNAs, 686 intronic and 49 exonic miRNAs with mRNA of 54 genes involving in oncogenesis were investigated. Interaction features of miRNAs with 5'UTR, CDS, 3'UTR of mRNA of each gene were revealed. High ability of miRNA to bind to 5'UTR in comparison with CDS and 3'UTR of mRNA. mRNA of studied genes are significantly different accoding to the number of binding miRNAs and location density of sites. Nucleotide of central part, 5'- or 3'-part of mRNA may contribute to main role in interaction energy with miRNA. Obtained results demonstrate ability of miRNA in gene expression regulation of genes involving in oncogenesis.