ГЕЛЬ ХРОМАТОГРАФИЯСЫМЕН mTOR КОМПЛЕКСТЕРІН БӨЛІП АЛУ

Abstract

mTOR is one of the central regulator of the cell. Targeting the mTOR pathway can impact physiological process including cell growth, proliferation and metabolism. mTOR is a unique target in cancer that may provide therapeutic benefit to patients with disease refractory to currently approved therapies. Therapeutic strategies combining mTOR inhibitors with other targeted therapies or cytotoxic agents may provide enhanced anticancer activity. However, a lot of efforts to study the mTORC1 and mTORC2 complexes and their functions have been done, but many questions about upstream signals and downstream effectors of mTORC2 and the possibility of mTOR to make other complex are still remains to be elucidated. In our study we found a new complex of mTOR by the corresponding to a bigger size than known two complexes by gel filtration chromatography.