In vitro cancerolytic activity of parasporal inclusions extracted from B. thuringiensis spp. israelensis

Abstract

The article presents the results of a screening program to find new anticancer protenious agents having the potential diagnostic and clinical applications in the field of oncology. Searching for new cancerolitic parasporal inclusions derived from bacteria of the genus Bacillus, having narrowly specific effect on certain tumor cell lines was provided. The result of this study is the discovery of 8 new producers of cancerolitic parasporal inclusions related to the strain B. thuringiensis spp. israelensis different H-serotypes. Activity of these parasporal inclusions was proved on cultures of tumor cells Hep G2 (hepatocellular carcinoma) and MiaPaca-2 (pancreatic carcinoma). Comparative analysis of the lack of cytotoxic activity on normal cells was carried out by the impact of an equal amount of the active substance in the cell line MDCK (kidney cell).