Кишечный микробиом и болезнь Альцгеймера
DOI:
https://doi.org/10.26577/eb-2018-4-1365Аннотация
Болезнь Альцгеймера является хроническим неизлечимым нейродегенеративным заболеванием и наиболее распространенной формой возрастной деменции. На развитие этой патологии у пожилых людей влияют различные факторы, такие как образ жизни, уровень стресса, генетическая предрасположенность, хронические заболевания, а также факторы окружающей среды. Одним из факторов, влияющих на состояние здоровья человека, и привлекающим все большее внимание ученых за последние 15 лет является кишечный микробиом. Микробиом кишечника - это сообщество микроорганизмов, колонизирующих желудочно-кишечный тракт и оказывающих огромное влияние на физиологию человека в норме и патологии. В последние годы накоплена значительная информация о том, что состав кишечной микрофлоры изменяется при различных патологических состояниях организма человека, включая нейродегенеративные заболевания. В связи с вышесказанным, в настоящей обзорной статье обсуждается связь кишечного микробиома и головного мозга и роль микроорганизмов, населяющих гастроэнтеральный тракт в развитии болезни Альцгеймера.
Ключевые слова: головной мозг, нейродегенерация, болезнь Альцгеймера, бета-амилоид, кишечник, кишечный микробиом.
Библиографические ссылки
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2019-01-31
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